Hidrating B5 Serum


The surface layers of the skin are supported from below by columns of fibers made up mostly of collagen and elastin. This network of fibers form the molecular sponge known as connective tissue. The spaces within this sponge are filled with a composition of water, protein complexes and hyaluronic acid. This serum is necessary for transportation of essential nutrients from the bloodstream, via the capillary network, to the living cells of the skin.


Pantothenic acid, also called vitamin B5 (a B vitamin), is a water-soluble vitamin - which means that the body can't store them - required to sustain life (essential nutrient).Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins.So,pantothenic acid is needed to form coenzyme-A (CoA), and is critical in the metabolism and synthesis of carbohydrates, proteins, and fats.

In chemical structure, it is the amide between D-pantoate and beta-alanine. Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every food, with high amounts in whole-grain cereals, legumes, eggs, meat, and royal jelly. It is commonly found as its alcohol analog, the provitamin panthenol, and as calcium pantothenate.

Only the dextrorotatory (D) isomer of pantothenic acid possesses biologic activity. The levorotatory (L) form may antagonize the effects of the dextrorotatory isomer.
Pantothenic acid is used in the synthesis of coenzyme A (CoA). Coenzyme A may act as an acyl group carrier to form acetyl-CoA and other related compounds; this is a way to transport carbon atoms within the cell. CoA is important in energy metabolism for pyruvate to enter the tricarboxylic acid cycle(TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle. CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine. CoA is incidentally also required in the formation of ACP, which is also required for fatty acid synthesis in addition to CoA.
Pantothenic acid in the form of CoA is also required for acylation and acetylation, which, for example, are involved in signal transduction and enzyme activation and deactivation, respectively.
Since pantothenic acid participates in a wide array of key biological roles, it is considered essential to all forms of life.As such, deficiencies in pantothenic acid may have numerous wide-ranging effects.

In skin care products, it helps to keep the skin moist and supple, stimulates cell growth and tissue repair and inhibits inflammation and reddening.

The topical use of vitamin B5, is based on good skin penetration and high local concentrations of vitamin B5 when administered in an adequate vehicle. Topical vitamin B5 acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with vitamin B5. Accelerated re-epithelization in wound healing, monitored by means of the transepidermal water loss as an indicator of the intact epidermal barrier function, has also been seen. vitamin B5 has been shown to have an anti-inflammatory effect on experimental ultraviolet-induced erythema. Beneficial effects of vitamin B5 have been observed in patients who have undergone skin transplantation or scar treatment, or therapy for burn injuries and different dermatoses. The stimulation of epithelization, granulation and mitigation of itching were the most prominent effects of formulations containing vitamin B5. In double-blind placebo-controlled clinical trials, vitamin B5 was evaluated for its efficacy in improving wound healing. Epidermal wounds treated with vitamin B5 emulsion showed a reduction in erythema, and more elastic and solid tissue regeneration. Monitoring of transepidermal water loss showed a significant acceleration of epidermal regeneration as a result of vitamin B5 therapy, as compared with the vehicle. In an irritation model, pretreatment with vitamin B5 cream resulted in significantly less damage to the stratum corneum barrier, compared with no pretreatment. Adjuvant skin care with vitamin B5considerably improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures, over 3 to 4 weeks. Usually, the topical administration of vitamin B5 preparations is well tolerated, with minimal risk of skin irritancy or sensitization.

Wound Healing : A study in 1999 showed that pantothenic acid has an effect on wound healing in vitro. It vas found that cell cultures with a concentration of 100?g/mL calcium D-pantothenate increased migration, and the fibres ran directionally with several layers, whereas the cell cultures without pantothenic acid healed in no orderly motion, and with fewer layers. Cell proliferation, or cell multiplication was found to increase with pantothenic acid supplementation. Finally, there were increased concentrations of two proteins, both of which have still to be been identified, that was found in the supplemented culture, but not on the control.
The Effect of Pantothenic Acid on Acne Vulgaris: One hundred patients of Chinese descent were included in one study, 45 males and 55 females. The age ranged from 10 to 30, and with about 80% between 13 and 23. The severity of the disease process varied. They were given 10 grams of pantothenic acid a day in four divided doses. To enhance the effect, the patients were also asked to apply a cream or serum consisting of 20% by weight of pantothenic acid to the affected area, four to six tines a day. With this treatment regimen, the response is as prompt as it is impressive. There is a noticeable decrease in sebum secretion on the face usually 2-3 days after initiation of therapy. The face becomes less oily. After two weeks, existing lesions start to regress while the rate of eruption of new acne lesions begins to slow down. In cases with moderate severity, the condition is normally in complete control in about eight weeks, with most of the lesions gone and new lesions only to erupt occasionally. In those patients with severe acne lesions, complete control may take months, sometimes up to six months or longer. In some of these cases, in order to get a more immediate response, it may even be necessary to step up the dose to 15-20 grams a day. In any event, the improvement is normally a gradual and steady process, with perhaps minor interruptions by premenstrual flare or excessive intakes of oily food. With this form of treatment, another striking feature is the size of the facial skin pore.
The pore size becomes noticeably smaller within one to two weeks, very often much sooner. Like sebum excretion, the pores will continue to shrink until the skin becomes much finer, giving the patient a much more beautiful skin.

This decrease in skin pore size is presumably related to sebum excretion. When an acne lesion is formed, there is in the epithelial cell of the hair follicle an accumulation of lipids, leaving the epithelial cells bulky and the lumen of the gland narrowed. When there is a concomitant increase in sebum flow, the follicle has no choice but to hypertrophy to accommodate the changes, resulting in an enlarged skin pore and coarse skin. With the administration of pantothenic acid, the whole process is reversed. Lipid metabolism becomes normal and efficient. The epithelium is no longer laden with fat droplets, there is a decrease in sebum excretion, the hypertrophy process is not required. The skin pores revert to a much smaller size and the skin becomes smooth and fine.

As acne lesions tend to subside spontaneously after puberty, some patients do not need a maintenance dose. But, if a patient is in his mid-teens, when the sexual characteristics have yet to fully develop, it may be necessary for replacement therapy to be implemented. This maintenance dose, can be lowered, or increased with the clinical symptoms. A maintenance dose will not only act as a preventive measure against sporadic eruption, but the extra pantothenic acid will help to ease the relative deficiency state, and likely improve the general health of the patient.

Hyaluronic acide is a non-sulfated glycosaminoglycan distributed widely throughout the body in the connective, epithelial, and neural tissues. It is one of the chief components of the extracellular matrix and contributes significantly to cell proliferation and migration. The average person has roughly 15 grams of hyaluronic acid in their body, one third of which is lost and replaced each day.
Hyaluronic Acid is a natural substance found in great abundance in young skin, synovial fluid and other tissues in humans and animals. Over time, oxy radicals, produced mostly through exposure to pollutants and sunlight, degrade and destroy hyaluronic acid. Fifty year olds are estimated to have less than half the hyaluronic acid they had in youth.Is one of the most effective moisturizing agents ever discovered by medical science.
Hyaluronic acid occurs naturally in the deeper layers of our skin (the dermis). It helps to keep skin smooth and "plump" through its ability to hold up to 1,000 times its weight in water.


The ability to retain and hold moisture is the secret to youthful, healthy, vibrant skin.

Aging robs us of this innate ability to hold in moisture. As we get older our bodies produce less and less Hyaluronic acid. The drop in Hyaluronic acid starts at around the age of 18-20 years. But after the age of 40 the down slide becomes apparent. Skin starts to lose its elasticity and lines and wrinkles appear.
Hyaluronic acid also supports the formation and maintenance of collagen, an important connective tissue. Collagen degradation is believed to cause a decrease in skin tone and elasticity.
Healthy, youthful skin comes from the inside. By replacing the components that naturally deplete with age, we can reverse the signs associated with aging.
Hyaluronic acid supplementation puts back in what is naturally lost to
Another important part of good skin is the ability to quickly heal wounds. This ability is slowly degraded with age. In part, it is due to the slowing down of cell mitosis, crucial aspect of cellular repair and regeneration. A possible contributing factor is also the decrease in the amount of Hyaluronic acid available in the body.

With properties like that, it is clear that hyaluronic acid is vital to:

Curb premature wrinkling  •  Increase skin hydration  •  Keep skin moist and smooth

Boost skin elasticity  •  Enhance collagen synthesis  •  Nourish healthy skin cell growth 

Promote firm skin tone  •  Support healthier joints




Honey. Is no simpler way to bring a smooth glow to your skin than with honey beauty recipes. Honey's ability to absorb and retain moisture make it an ideal ingredient in this serum as it helps keep skin hydrated and fresh and prevents drying. It is known that ancient beauties regularly applied a mixture of honey and milk to the face to keep the skin young-looking, radiant, and smooth.

Honey's natural antioxidant and anti-microbial properties help to protect the skin from the damage of the sun's rays, supports the skin's ability to rejuvenate and refresh depleted skin, leaving it feeling silky soft and supple. One of the most common skin benefits of honey is related to minor acne treatment. Honey absorbs impurities from the pores on the skin.

All-natural honey has been used as a beauty product since the days of Cleopatra and it continues to be used today. Honey is a natural humectant, which means it has the ability to attract and retain moisture. The skin's ability to stay moist (or hydrated) is an important factor in its ability to maintain softness, suppleness and elasticity. As skin ages, or as it is exposed to environmental stresses and chemical agents, it loses its ability to retain water; it becomes dry and appears wrinkled. Honey's natural hydrating properties make it ideal for use in also in moisturizing products.
Studies have also revealed that honey has significant natural antioxidant properties. Antioxidants play a role in protecting the skin from the damage of UV rays, and aiding in skin rejuvenation. Prolonged exposure to the sun's UV radiation can cause skin damage, premature aging and even skin cancer.

A recent review of medical research documents honey's effectiveness as an antimicrobial agent. Antimicrobial agents inhibit the growth of certain bacteria. According to Janice Cox, author of Natural Beauty at Home, "Honey's antimicrobial properties make it useful for the treatment of minor acne flare-ups. Also, unlike some acne treatments, honey doesn't dry the skin." Honey is antimicrobial for many reasons, including its high sugar content, which limits the amount of water available to bacteria for growth; its relatively high acidity (low pH); and its low protein content, which deprives bacteria of nitrogen needed for growth. The presence in honey of hydrogen peroxide, and the antioxidants honey contains, also inhibit bacterial growth.


Benefits of serum: Like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Moisturizer to improve the smoothness, suppleness and texture of your skin. Supplements the skins natural biological replacement of hyaluronic acid. Skin feels more resilient and extraordinarily smooth to the touch. Facilitates better absorption of vitamin C .Perfect base for all types of make-up. Restores youthful translucency and buoyancy to the skin. Smoother, more radiant looking skin will be noticed in 3 - 6 weeks.

Can be used by women and men including those with sensitive skin. The serum instantly gives your skin a silky smooth texture. Ideal for all skin types.

Directions: Cleanse and tone. Apply Dermaflora Vital Vitamin C serum (If you are using Dermaflora D'or day or night cream, or Deramaflora Hydrolight  cream with ceramide or Dermaflora Hydrolight cream with liposome, apply Dermaflora Vital Hydrating B5 Serum first.) ApplyDermaflora Vital Hydrating B5 serum. Apply moisturizer. Note: This product begins its moisturizing work beneath the surface of your skin. It is not intended for surface hydration, so you must use an additional moisturizer. During the first two or three weeks, absorbency may be greater for some people than others. Begin by Hydrating B5 Seruma little more generously for the first few weeks. Gradually you will notice that the skin no longer absorbs the fluid as quickly. This is a sign that your skin has restored much of its moisture balance. Once this happens, only a small amount of Hydrating B5 Serum is required to maintain this. Your skin will regulate the intake automatically.

To use: Once or twice a day, with moisturizer.

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